Giving a full dose of Moderna’s Covid-19 vaccine as a booster shot provides more antibody protection against the Omicron variant than currently authorised half-strength injections, the company said Monday, IgbereTV reports.
The lab study measured the levels of Omicron-neutralising antibodies in blood samples from 40 people who had low levels of these antibodies before getting the booster.
The current recommendation is to give 100 micrograms of the Moderna jab as a first and second dose for protection from Covid-19, followed by a 50-microgram booster.
Antibodies were measured 29 days after booster participants got the third jabs, with half getting a 50 microgram dose and half getting 100 micrograms.
Moderna says preliminary data show antibody response to Omicron at the 50 microgram dose increased 37-fold — but when the dose was doubled, antibody levels increased 83-fold.
Moderna CEO Stephane Bancel called the results “reassuring”, adding that the company is continuing to develop an Omicron-specific jab.
The statement says clinical trials for a targeted vaccine are likely to begin in early 2022.
Experts urge caution when interpreting lab studies, saying real-world evidence is needed to determine protection against transmission and illness
